It has been shown to be decreased in the neocortex and CSF of Alzheimer’s disease patients,14,15 and in the neocortex of dementia with Lewy bodies,16 Parkinson’s disease,17 and PSP patients.17 Despite this, the mechanism behind the association between CRH and these diseases remains unclear. The gene discussed is CRH; the disease is supranuclear palsy, progressive, 1.