The decrease of CRH in Lewy body disease and atypical PS carries several biological implications, as CRH is involved in stress, inflammation, metabolism and reproduction, among others.27 Consequently, abnormal levels of CRH would impact factors known to contribute to neurodegenerative diseases, particularly inflammation.28 CRH dysregulation would suggest a disproportional inflammatory response, which is commonly observed in these diseases. This evidence concerns the gene CRH and Lewy body dementia.