Notably, atypical PS individuals [PSP = 25 (SAA− = 23; SAA+ = 2); MSA = 12 (SAA− = 12; SAA+ = 0)] showed a stronger downregulation in CRH (Fig. 1E) than the Lewy body disease group, when compared with SAA− CUI (P = 3.1e−10, AUC = 0.85) (Supplementary Table 3). This evidence concerns the gene CRH and multiple system atrophy.