However, because this decrease is not limited to synucleinopathies and it does not occur when comparing SAA− to SAA+ Alzheimer’s disease/frontotemporal dementia/vascular dementia, dopaminergic dysfunction may instead be the cause of CRH decrease, which in turn could be associated to the stress and inflammatory aspect of these diseases. Here, CRH is linked to early-onset autosomal dominant Alzheimer disease.