However, CRH downregulation correlated with impaired cognition in Lewy body disease individuals (Fig. 2C–F), specifically, worse global cognition (mPACC, R = 0.4, P = 0.00061), memory score (ADAS-Cog, R = −0.4, P = 0.0032), cognitive speed (AQT, R = −0.4, P = 0.00032) and visuospatial score (VOSP, R = 0.4, P = 0.00076). Here, CRH is linked to Lewy body dementia.