The denervation of dopaminergic neurons is common in Lewy body disease and atypical PS,22,23 and the PVN, where CRH is mainly produced, is subject to excitatory and inhibitory dopaminergic regulation.24-26 As such, the loss of dopaminergic innervation occurring in these diseases might contribute to CRH dysregulation. The gene discussed is CRH; the disease is Lewy body dementia.