In BioFINDER-2, CSF CRH was reduced in SAA+ Lewy body disease and SAA+ CUI individuals compared with SAA− CUI (P = 3.3e−05, AUC = 0.79; P = 2.9e−03, AUC = 0.80) (Fig. 1A and C; Supplementary Table 3). The gene discussed is CRH; the disease is Lewy body dementia.