INS and Hyperglycemia: In another study, lupeol treatment effectively reduced the expression of SREBP-1c protein and restored it to the control level through activating the regulation of insulin signaling molecules and glucose oxidation in the liver conducted on type 2 diabetic rats that previously had elevated levels of the protein in the liver due to a high-fat diet and sucrose-induced hyperglycemia (Sohag et al., 2022).