We also observed that the median time to onset of GLP-1 RAs-associated acute pancreatitis was 92 (range: 0–3,312) days across ICSRs that provided both drug initiation and AP onset times, and 2.5 months of the case series, indicating a longer onset duration compared to other gastrointestinal adverse events triggered by GLP-1 RAs (Zhou et al., 2022). This evidence concerns the gene GCG and acute pancreatitis.