STAT3 and hyperlipidemia: Cheng et al. induced hyperlipidemia in mice using a HFD and discovered that 6-shogaol inhibited hypertrophy and hyperplasia of white adipose tissue (WAT) in mice, down-regulating the TLR3/IL-6/JAK1/STAT3 and PCNA signaling axes, thereby improving liver metabolic disorders and insulin resistance (Cheng et al., 2022).