ADIPOR1 and Other metabolic disease: In another study, Bunbupha et al. demonstrated that nobiletin could moderate the effects of HFD on the expression of liver adiponectin receptor 1 (AdipoR1) and gp91phox, thereby regulating adiponectin levels, reducing oxidative stress, and alleviating metabolic disorders in rats after high-fat intake (Bunbupha et al., 2021).