Reducing oxidative stress levels in the liver mediated by nuclear factor E2-related factor 2(Nrf2), promoting liver protein synthesis and bile metabolism, and regulating the expression of transforming growth factor-β1 (TGF-β1) and plasminogen activator inhibitor-1(PAI-1) during disease progression, thereby inhibiting the activation of hepatic stellate cells, collagen proliferation, and promoting the degradation of extracellular matrix, thus preventing liver fibrosis and exerting a hepatoprotective effect. Here, SERPINE1 is linked to Hepatic fibrosis.