Ameliorates NAFLD involves inducing the activation of autophagy, forming a complex regulatory network of key compounds (quercetin, ellagic acid, kaempferol, formononetin, stigmasterol, isorhamnetin and luteolin), key targets (CAT, AKT, eNOS, NQO1, HO-1 and HIF-1α) and related energy metabolites (NADP and succinate), thereby alleviating oxidative stress, ER stress, and mitochondrial dysfunction. The gene discussed is HIF1A; the disease is metabolic dysfunction-associated steatotic liver disease.