In addition, vitexin significantly reduced hepatic macrophage infiltration, obviously downregulated the mRNA and protein expressions of hepatic SREBP-1c, FAS, ACC, and could significantly inhibit the expressions of TLR4/NF-κB signaling in NAFLD mice (Li C. et al., 2020). The gene discussed is TLR4; the disease is metabolic dysfunction-associated steatotic liver disease.