IGF2 and neoplasm: According to Dave et al. and Eason et al., the whey protein hydrolysate exhibited anti-tumor effects in MCF-7 cell and rat models, as evidenced by a decrease in tumor diversity, tumor incidence, and cell proliferation, as well as reduction in the expression of cyclin D1 and IGF-2 (Eason et al., 2004; Dave et al., 2006).