Furthermore, FebLf NCs exhibited antiproliferative effects against breast cancer cells, decreased cell viability, inhibited clone formation, reduced the diameter of 3D tumor spheroids, enhanced mitochondrial depolarization, reduced tumor volume in mice, and activated the pro-apoptotic protein of caspase-3, which was associated with the activation of the P13K signaling. This evidence concerns the gene CASP3 and breast cancer.