Cell proliferation, tumor colony, cell viability, tumor volume, tumor spheroid size, invasion↓; surviving, livin↓, cytochrome C, mitochondrial membrane depolarization ↑, LRP1, LRP 2, TFR, TFR 1, TFR 2, DMT-1, ferroportin, ferritin-heavy chain and ferritin-light chain receptor genes, caspase-3↑; tumor volume↓. The gene discussed is CASP3; the disease is neoplasm.