Lf-Doxo-MMNPs (Size: 130 ± 1.48 nm), a therapeutic NP integrating chemotherapy, magnetic field, and photothermal tools, demonstrated prolonged blood circulation as well as notable cytotoxicity in breast cancer cells/tissues by activating Bax and caspase-3 and modulating CXCL12 and CXCR7, thereby causing necrosis and apoptosis, blocking cell cycle at the S1 and subG1 phases, and inducing ROS accumulation (Sharifi et al., 2020). This evidence concerns the gene CASP3 and breast cancer.