Cell cytotoxicity, apoptosis, IFN-γ and IL-2↑; cell migration, invasion, tumor volume, tumor weight, mitosis, metastasis, IL-10 and IL-1β, lipid peroxidation and NO Levels↓; ICAM, iNOS, MMP-9, NF-κB, G-CSF, GM-CSF, IL-4, TNF-α, iNOS↓; ex vivo angiogenesis was obstructed. Here, CSF2 is linked to neoplasm.