Vitexin, a flavonoid-like compound derived from Vitex negundo L. var., promotes the polarization of M1 macrophages and inhibits M2 polarization by increasing the expression of STAT1/p-STAT1, thereby inhibiting tumor growth in colon and breast cancer mice (X. Yuan, 2019; Yuan et al., 2022). This evidence concerns the gene STAT1 and breast carcinoma.