Ovarian cancer, like many other cancers, is characterized by alterations in various epigenetic regulators, including Enhancer Of Zeste Homolog 2,SNF-related, Matrix-associated, Actin-dependent Regulator of Chromatin2/4, and AT-rich Interactive Domain-containing Protein 1A (EZH2, SMARCA2/4, and ARID1A). The gene discussed is EZH2; the disease is cancer.