Another group using serum samples from ovarian cancer patients, healthy donors, and ovarian cancer cell lines exhibited differential expression of tRFs; the results indicated that tRF-03357 promoted proliferation, migration, and invasion of Ovary Adenocarcinoma 3 (SK-OV-3) cells and downregulated Homeobox Containing 1 (HMBOX1) (89). The gene discussed is HMBOX1; the disease is ovarian cancer.