1.USP22 enhances gastric cancer advancement by influencing FOXO1 and YAP signaling pathways through c-Myc/NAMPT/SIRT1.2.USP22 boosts SOS1 levels in gastric cancer, activating Ras/Erk and Ras/PI3K/Akt pathways.3. USP22 connects with RNF220 to influence the Wnt/β-catenin pathway, promoting gastric cancer cell development. The gene discussed is SIRT1; the disease is gastric cancer.