The transcriptional repressors of E-cadherin include E-box-binding homeobox 1 (ZEB1), zinc finger E-box-binding homeobox 2 (ZEB2), twist related protein (Twist), zinc Finger proteins, Snail and Slug, etc., which initiate EMT through TGF-β, Wnt, and phosphatidylinositol 3’kinase serine/threonine kinase (PI3K/AKT) pathway and indicate poor prognosis of breast cancer (26). Here, ZEB2 is linked to breast carcinoma.