The CNVs of the disulfidptosis genes also occurred across pan-cancer, with 2 % CNV frequency for RPN1, and 1 % CNV frequencies for OXSM, NUBPL, NCKAP1, NDUFA11, LRPPRC, NDUFS1, GYS1, SLC7A11, and SLC3A2 (Fig. 2C). This evidence concerns the gene NDUFS1 and cancer.