GNE-3511 produced only a minor or no reduction in colony formation in HNSCC cells lacking amplified MAP3K13 (MSK921 and BICR22) (Figure 1G, H) and in BEAS2B cells, an immortalized and non-tumorigenic human lung epithelial cell line (Figure S1B). The gene discussed is MAP3K13; the disease is head and neck squamous cell carcinoma.