MYC and head and neck squamous cell carcinoma: Dox-inducible depletion of LZK with two unique LZK shRNAs (as described in Edwards et al. and Figure S2E) (1) reduced c-MYC abundance in 3q amplicon-positive HNSCC cells (CAL33 and BICR56) but not control cells (MSK921) (Figure 2D, E).