We selected regions of interest for model development, surrounding suspected neurodegenerative disease (NDD) risk loci with 250 kilobase (kb) buffers, including Parkin (PRKN; chr6:161347557–162727802 [hg38]), Leucine Rich Repeat And Ig Domain Containing 2 (LINGO2; chr9:27948085–29213000 [hg38]), and Microtubule Associated Protein Tau (MAPT; chr17:45894381–46028333 [hg38]). The gene discussed is MAPT; the disease is Neurodevelopmental delay.