PDPN and adenocarcinoma: We find that the overlap CCF between PDPN (CAF marker) and VCAN (inflammatory marker) increases while the overlap CCF between PDPN and COL6A2 decreases in FAP adenocarcinoma/CRC samples indicating that CAFs are present in close proximity to the inflammatory region of the FAP affected tissue for promoting tissue malignancy and are not correlated with normal fibroblasts (Fig. 4e).