These findings underscore a profound alteration of the gut microbiota under the dual pressures of alcohol and NLRP3 deficiency, accompanied by an increased relative abundance of proinflammation‐related microbiota in Nlrp3−/− mice with ALD, such as Deferribacterota (Mucispirium) and Enterobacteriaceae.30, 31, 32. The gene discussed is NLRP3; the disease is hyperinsulinemic hypoglycemia, familial, 4.