Nlrp3−/− and Gsdmd−/− ALD mice showed an increased gut bacterial load, decreased ileal expression of E‐cadherin, more severe ileitis, pronounced liver damage, steatosis and higher plasma levels of FITC‐dextran, D‐LA and ZO‐1 compared with WT mice. This evidence concerns the gene TJP1 and Crohn ileitis.