Although SFT treatment significantly suppressed the growth of colony spheroids in ICC‐TRCs, as well as migration and invasion in vitro, silencing the expression of RARɑ by siRNA could significantly reverse these inhibitory effects (Figure 2F,G), which markedly decreased the mRNA and protein levels of RARα (Figure S10, Supporting Information). The gene discussed is RARA; the disease is intrahepatic cholangiocarcinoma.