Previous studies indicated that the binding of P‐selectin to PSGL1 could facilitate the growth and metastasis of cancer.[21, 24] Worthy of note is that PSGL1 directly binds to cytoskeleton via ezrin/radixin/moesin (ERM) complex.[25] Cytoskeleton‐related components, cytoskeleton remodeling as well as its interaction with CSCs play important roles in maintaining and promoting the biological behavior of CSCs.[26] We found that SFT decreased the level of filamentous‐actin (F‐actin) in ICC‐TRCs (Figure 4G). This evidence concerns the gene SELPLG and cancer.