C5 and colorectal cancer: For instance, P‐selectin mediates the proliferation and invasion of glioblastoma by altering the activation state of microglia/macrophages.[24] Platelets‐derived P‐selectin promotes colorectal cancer growth and metastasis by activating PSGL‐1/JNK/STAT1 signaling pathway, which promotes C5 transcription and activates the C5a/C5aR1 axis in tumor associated macrophages.[39] We found that SFT treatment or P‐selectin intervention significantly destroyed the cytoskeleton of ICC‐TRCs.