SIRT1 and metabolic dysfunction-associated steatohepatitis: Oxidative stress due to reactive oxygen species plays a major role in MASH progression and has been linked to DNA damage and pathological polyploidization.[48] To evaluate whether modulation of DNA damage repair and cellular bioenergetics would improve hepatic fibrosis, we used our model to evaluate a chemical series comprising 50 small molecule modulators of OGG1, SIRT1, and NAMPT.