OGG1 and Hepatic fibrosis: These compounds included TH10785, a cellularly active organocatalytic switch that increases the enzymatic activity of OGG1 on apurinic sites by 20‐fold.[49] The anti‐fibrotic effects of TH10785 were confirmed using secreted markers of hepatic fibrosis, as well as by IHC which showed a significant reduction of collagen I deposition (Figure 4b,c).