In prior renal-disorder-related studies, it was documented that melittin played a role in modulating the nuclear translocation of the nuclear factor erythroid 2-like 2 (Nrf2), a pivotal transcription factor responsible for upregulating the expression of important antioxidant genes such as heme oxygenase-1 (HO-1) [20]. This evidence concerns the gene HMOX1 and kidney disorder.