While RB1 on the 13q14.2 locus has been extensively studied due to its established tumor suppressor function [16, 52, 53], the 13q14.2 region encompasses additional genes that may significantly influence the development and progression of BCa beyond RB1. This perspective is supported by both publicly available sequencing data and our own research, which demonstrate the variable extent of 13q14.2 losses across various BCa cell lines and patient samples (Fig. S9). This evidence concerns the gene RB1 and neoplasm.