The hypo-down genes were involved in DNA replication, GABAergic synapse, pentose and glucuronate interconversions, sphingolipid signaling pathway, cell cycle-yeast, NHEJ, cAMP signaling pathway, pathogenic Escherichia coli infection, adrenergic signaling in cardiomyocytes, cell cycle, parathyroid hormone synthesis, secretion and action, hepatitis B, purine metabolism, autophagy yeast, and meiosis yeast (Fig. 6C). This evidence concerns the gene PTH and hepatitis B virus infection.