The hyper-up genes were primarily associated with alanine, aspartate and glutamate metabolism, plant-pathogen interaction, RNA transport, spliceosome, carbon fixation in photosynthetic organisms, phenylalanine, tyrosine and tryptophan biosynthesis, fluid shear stress and atherosclerosis, lipid and atherosclerosis, phenylalanine metabolism, isoquinoline alkaloid biosynthesis, tropane, piperidine and pyridine alkaloid biosynthesis, circadian rhythm—plant, morphine addiction, PI3K-Akt signaling pathway, and longevity regulating pathway—multiple species (Fig. 6B). This evidence concerns the gene AKT1 and atherosclerosis.