GSDME and neoplasm: Notably, in tumor microenvironment (TME) with H2O2 accumulation, the structure of specific iron ruthenium pyroptosis inducer (SIRPI) is altered and switched to an ROS generator, which specifically generate large amounts of singlet oxygen (1O2) and hydroxyl radical (·OH) and trigger the specific pyroptotic tumor cell death via the caspase‐3/ gasdermin E (GSDME) pathway.