CXCL10 and neoplasm: Independent of the effects of T cell transfer, a set of genes characteristic of an IFNα response (for example, Irf7, Isg15 and Cxcl10) was higher in NTT TMEs than in RTT TMEs, which suggested that both IFN-I and IFN-II cytokines modulate an inflammatory TME in NTT tumours (Extended Data Fig. 7d,e).