PDCD1 and neoplasm: We observed similar repolarization of the myeloid compartment in the YUMM3.3 (BrafV600E, Cdkn2a–/–) model, in which RTT tumours failed to respond to ICB (that is, anti-PD-1 and anti-CTLA-4 agents)15 (Extended Data Fig. 1g–j).