These findings suggest that MT-6194 can broadly suppress the increased expressions of molecules in SSc patients at high risk for PAH by inhibiting both the NF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\kappa$$\end{document}B and JAK/STAT pathways. The gene discussed is SOAT1; the disease is systemic sclerosis.