MT-6194 broadly reduced the gene expressions of the molecules upregulated in SSc patients with high risk for PAH due to simultaneous inhibition of both the JAK/STAT and NF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\kappa$$\end{document}B pathways. This evidence concerns the gene SOAT1 and pulmonary arterial hypertension.