ADSL and bacterial infectious disease: Specifically, it undergoes a burst release within 8 h of implantation, enabling the concentration of AMPs to reach nearly three times the MIC, effectively inhibiting bacteria introduced during the initial implantation.[19, 42] Subsequently, the release of AMPs transitions into a sustained period, promoting favorable conditions for bone integration.[12c] Importantly, in the event of a recurrent bacterial infection, the implant exhibits responsiveness to the decrease in pH, releasing a sufficient amount of AMPs (reaching the MIC within 48 h) (Figure 1I and 2G).