Consider for example that mutations in the PROSC gene cause a severe form of epilepsy in humans (Darin et al., 2016; Johnstone et al., 2019; Plecko et al., 2017; Shiraku et al., 2018), whereas the knockout of yggS in E. coli have no apparent effect on growth capabilities in either rich or minimal liquid growth medium (Babor et al., 2023). The gene discussed is PLPBP; the disease is epilepsy.