CX3CL1 and Huntington disease: In particular, STRING analysis highlighted the significant involvement of the PPI network in several biological processes that are known to be disrupted in HD, including apoptotic processes associated with the inflammatory response such as “regulation of hippocampal neuron apoptotic process,” “positive regulation of microglial cell migration,” “positive regulation of I‐kappaB phosphorylation,” and “macrophage migration.” These processes as well as “synapse pruning” and “autocrine signaling” are regulated mainly by CX3CL1, CX3CR1, and ITGAM in this network.