TNNT2 and obesity due to melanocortin 4 receptor deficiency: To investigate whether TXNIP/NLRP3 inflammasome activation contributes to obesity‐induced cardiomyopathy, we specifically overexpressed TXNIP protein in cardiomyocytes by delivering recombinant adeno‐associated virus serotype 9 encoding TXNIP (rAAV9‐cTnT‐TXNIP) into 6‐week‐old WT or NLRP3‐/‐ mice, with rAAV9‐cTnT‐null as a control (Figure 5C).