SH-SY5Y neuroblastoma cells provide insight into cellular interactions and toxicity of neuropathological amyloid proteins such as Aβ, α-Syn, and Tau with both approaches of exogenous exposure and endogenous expression, in a simplified in vitro system (Kakinen et al., 2021, Polanco and Götz, 2022, Rodríguez-Losada et al., 2020). This evidence concerns the gene MAPT and neuroblastoma.