GLP1R and Anxiety: Indeed, in addition to a well-established hypophagic role of central GLP-1, solid evidence supports an anxiogenic role in male and female rats, in which anxiety-like behaviours increase upon GLP-1 receptor stimulation in the central amygdala [33] or supramammillary nucleus [37], and decrease following GLP-1 receptor knockdown in the bed nucleus of the stria terminalis [36].