Therefore, nutritional strategies aimed at increasing SCFAs may be beneficial for patients with CKD, and a single-center, non-randomized study showed that SCFA supplementation reduced C-reactive protein, IL-2 and IL-17, oxidative stress, enteric-derived indoxyl sulfate, and p-cresol sulfate in patients with maintenance hemodialysis [14]. The gene discussed is IL17A; the disease is chronic kidney disease.