,44,45,46,47 Overexpression of TKT was closely associated with aggressive hepatocellular carcinoma features,48 and 6PGD was shown to promote metastasis,49 while suppression of 6Pgd attenuates cell proliferation and tumor growth42 and overcomes cisplatin resistance50 and Tkt inhibition sensitizes cancer cells to targeted therapy and reduces growth of metastatic lesions.48 This evidence concerns the gene TKT and hepatocellular carcinoma.