Following multivariate adjustment, high TACC3 expression remained a significant risk factor for OS in the NSCLC (HR = 2.39; 95% CI, 1.11–5.17; P = 0.027) and LUAD (HR=1.79; 95% CI, 1.22–2.61; P = 0.003) datasets (Fig. 3C and D). Here, TACC3 is linked to non-small cell lung carcinoma.