We found that all the included studies on the evaluation of the motor ability of children with ADHD used VR game training, and the completion of VR game training required the participation of children’s physical activities, which can change cerebral blood flow, cause the release of serotonin and brain-derived neurotrophic factor, promotes the increase of catecholamine and proteinase, and then improve the core symptoms of children with ADHD [51, 52]. This evidence concerns the gene BDNF and attention deficit-hyperactivity disorder.