CD4 and neoplasm: The PCDS score showed a negative correlation with key aspects of the cancer immune cycle, including the presentation of cancer antigen priming and activation, the recruitment of B cells, and the recruitment of CD4+ T cells, dendritic cell recruiting, Th17 cell recruiting, Th2 cell recruiting, Th22 cell recruiting, Treg cell recruiting, and T cell infiltration into the tumour stroma (Figure 8B).