CD8A and Familial prostate cancer: Patients with higher ISUP GG (3–5) disease had a significantly greater density of CD8+ cells in both intratumoral and peritumoral regions within their prostate cancer specimen compared to patients with lower grade disease (intratumoral median: 207.4/mm2 versus 142.3/mm2; p = 0.01; peritumoral median: 118.0/mm2 vs 78.5/mm2; p = 0.02) as demonstrated in Table 2.