We found that HAR1A and HAR1B have a significant positive correlation in both datasets (Fig 1A and 1D), HAR1A and REST have a significant negative correlation in both datasets (Fig 1B and 1E), and HAR1B and REST have a significant negative correlation in lower grade gliomas (Fig 1C), but unexpectedly, do not correlate in the GBM dataset (Fig 1F). The gene discussed is REST; the disease is central nervous system cancer.