Earlier studies have shown that epigenetic changes in the myeloid-derived suppressor cells (MDSCs), dendritic cells (DCs), tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), natural killer cells (NK cells) and regulatory T cells (Tregs) in the TME persuaded immunosuppressive function through the secretion of inhibitory cytokines, including IL-10 and TGF-β [6]. The gene discussed is IL10; the disease is neoplasm.