Earlier studies have shown that epigenetic changes in the myeloid-derived suppressor cells (MDSCs), dendritic cells (DCs), tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), natural killer cells (NK cells) and regulatory T cells (Tregs) in the TME persuaded immunosuppressive function through the secretion of inhibitory cytokines, including IL-10 and TGF-β [6]. This evidence concerns the gene TGFB1 and neoplasm.