CXCL12 and periodontitis: In both in vitro and rat models of periodontitis, the sustained release of DTT and SDF-1 led to the hydrogel with a significant reduction in ROS levels, reactivation of the Wnt/β-catenin signaling pathway in osteoblasts, and restoration of their osteogenic capability, thereby suggesting that a combination of DTT and SDF-1 could be promising for use in periodontal therapy.