Dermal fibroblasts from 10 SSc patients were treated with salirasib in the presence of TGF‐β1, and mRNA levels of H‐Ras and genes related to fibrosis, such as COL1A1, COL1A2, CTGF, TGF‐β1, fibronectin, ACTA2, and MMP1 was measured by real‐time PCR. This evidence concerns the gene COL1A1 and systemic sclerosis.