CD83 and neoplasm: To dissect how CD83 affects tumor growth and the associated immune microenvironment, we performed scRNA-seq on CD83OE and CD83KO tumors, confirming a significant 2.98 log2 fold change increase (adjusted P value < 2.2e−16) in CD83 expression within CD83OE tumor cells when compared with control tumor cells (Fig. 3A; Supplementary Fig. S3E).