CD8A and neoplasm: Intriguingly, the total number of tumor-infiltrating CD8+ T cells per field of view (FOV) was marginally increased in CD83KO tumors as compared with CD83OE (11.07 cells/FOV CD83KO vs. 6.93 cells/FOV CD83OE, Tukey MCT CD8: CD83KO vs. CD83OEP value = 0.0270); however, examination of the transcriptional profiles of these cells using our scRNA-seq dataset revealed that T cells from CD83KO tumors were likely nonfunctional, having the highest expression of exhausted T-cell markers (Fig. 4C).