On the other hand, later in infection, a RIG-I KO abolishes the antiviral activity of the canonical RIG-I pathway, which induces high levels of IFN mRNA expression and then causes the expression of various antiviral proteins, resulting in the induction of delayed but sufficient NP mRNA (Fig. 5e) to support virus propagation (Fig. S13). This evidence concerns the gene IFNA1 and infection.