It seems likely that biallelic inactivation of both DICER1 allelesis required for the tumor to develop properly, as this phenomenon has been reportedfor various DICER1-related neoplasia, such as PPBs, Wilms tumors, embryonalrhabdomyosarcoma and anaplastic sarcomas of the kidney, and in different subtypes ofthyroid cancer (31, 32, 33, 34, 35, 36, 37). This evidence concerns the gene DICER1 and neoplasm.