MLH1 and cranioectodermal dysplasia: In addition, it is well established that small bowel adenocarcinomas associated with CeD (CeD‐SBAs) are mainly characterized by epigenetic alterations such as MLH1 methylation leading to microsatellite instability (MSI) in comparison to controls (i.e. sporadic SBAs, S‐SBAs) and SBAs associated with Crohn's disease (CrD‐SBAs) [26], although the molecular mechanisms underlying these alterations remain unclear.