As expected, the MLH1 gene was significantly downregulated in CeD‐SBAs (p = 0.024) compared with S‐SBAs; in fact, the CeD‐SBA group was significantly enriched by MLH1‐negative and MLH1 hypermethylated adenocarcinomas, as already reported by Vanoli et al [26]. This evidence concerns the gene MLH1 and cranioectodermal dysplasia.