Specifically, chemokines and cytokines associated with these pathways include CCL17, CXCL2, CXCL8, CCL3, CCL4 and IL1B that have been reported to negatively regulate the immune system and promote tumour development (Table S11).68, 69, 70, 71, 72, 73, 74, 75. This evidence concerns the gene CCL4 and neoplasm.