It is worth noting that the interaction between HLA‐II molecules (such as HLA‐DRA, HLA‐DRB1, HLA‐DRB5, HLA‐DQB1, HLA‐DPB1, HLA‐DPA1, HLA‐DMB and HLA‐DMA) and the receptor CD4 was exclusively detected in the cell communication between malignant cells from single‐primary tumours and Tregs. The gene discussed is HLA-DMB; the disease is neoplasm.