More important, previous studies found that pyroptosis marker (NLRP3, CASP1) was increased in AAA6 and pyroptosis could promote a variety of important pathological processes of AAA (such as smooth muscle cell phenotype transformation,7 T cell infiltration8) to induce the formation of AAA, which indicated pyroptosis played a critical role in mediating AAA formation. Here, CASP1 is linked to triple-A syndrome.