In this study, we found that circHipk3 downregulation significantly suppressed pyroptosis markers (NLRP3, GSDMD and cleaved CASP1) in vitro of macrophage and in Ang II‐ and PPE‐induced AAA model, whereas upregulated of circHipk3 increased NLRP3, GSDMD and cleaved CASP1 expression level in Ang II‐ and PPE‐induced AAA model, which suggested that circHipk3 might contribute to the activation of macrophage pyroptosis in AAA. Here, GSDMD is linked to triple-A syndrome.