In our study, circHipk3 overexpression upregulated pyroptosis marker GSDMD, CASP1, inflammatory cytokines IL‐1β, IL‐18, MMP2/9 and macrophage marker CD68 in vitro of macrophage and AAA model, promoted elastin fibres degradation, increased the abdominal aorta average maximum diameter and the incidence rate of the aneurysm in PPE‐ and Ang II‐induced AAA models. Here, GSDMD is linked to triple-A syndrome.