Immunohistochemical staining revealed that the macrophage marker CD68, the pyroptosis marker NLRP3, CASP1 and the metalloproteinases MMP2 and MMP9 displayed identical tendencies to those observed in Ang II‐induced AAA when circHipk3 was knocked down (Figure 5E–I). The gene discussed is AGT; the disease is triple-A syndrome.