NLRP3 and triple-A syndrome: After confirming successful transduction of aortic macrophages (Supporting Information Figure S10A) and assessing transduction efficiency (Supporting Information Figure S10B), we observed that overexpression of circHipk3 specifically in macrophages targeted to the abdominal aorta led to an increase in AAA lesion size (Supporting Information Figure S10C), upregulation of NLRP3 expression (Supporting Information Figure S10D).