Many pathways implicated in carcinogenesis and tumor development, including the TP53, Notch, Sonic Hedgehog, and Jak/Stat3 pathways, crosstalk with the classical Wnt pathway.[12, 43, 44] Through mass spectrometry (MS) and transcriptomic analyses and sequential validation, we discovered that adavivint specifically attenuated ADAM10/NOTCH2 signaling at the protein level. Here, NOTCH2 is linked to neoplasm.