TCF7L2 and colon carcinoma: In colon carcinoma, the presence of a stable and constitutively active β‐catenin/TCF7L2 signaling pathway indicates the crucial role of TCF7L2 in carcinogenesis.[52, 53] Among the four members of the TCF/LEF family, TCF7L2 exhibited the highest mRNA levels, indicating its pivotal role.