In CRC, activation of the Wnt and Notch pathways is associated with chemotherapy resistance, including resistance to 5‐FU and oxaliplatin.[55, 56, 57] Among the downstream genes of the canonical Wnt pathway, we observed that ADAM10/NOTCH2/TCF7L2 signaling regulates MYC and JUN more prominently than the other genes. This evidence concerns the gene NOTCH2 and colorectal carcinoma.