The synergistic index of adavivint and FOLFOX regimen was also calculated for other organoids, revealing synergistic effects in nearly all CRC organoids, particularly in those with high ADAM10 and NOTCH2 levels and enrichment scores of the Wnt pathway, such as the P and LM5L organoids (Figure 7J). This evidence concerns the gene ADAM10 and colorectal carcinoma.