revealed that targeting NOTUM, an extracellular palmitoleoyl‐protein carboxylesterase that antagonizes canonical Wnt signaling in mammals, is an effective approach for arresting tumor progression and metastasis in CRC.[54] Additionally, we also revealed that TCF7L2 could directly bind to the promoter of NOTCH2 ligand JAG1 and promote transcription of JAG1, which was similar with previous study.[27] Adavivint treatment decreased JAG1 expression in CRC organoids. Here, NOTCH2 is linked to colorectal carcinoma.