ADAM10 and neoplasm: Members of the ADAM family are multi‐domain transmembrane metalloproteases that cleave numerous cell surface proteins and activate downstream pathways involved in tumor development, including NOTCHs and their ligands.[25, 45] IP with anti‐ADAM10 and western immunoblotting with an ubiquitin antibody indicated that adavivint degrades ADAM10 via the ubiquitin–proteasome system.[46] Notably, we observed direct interactions between ADAM10 and NOTCH2; however, no direct interactions were detected between ADAM10 and the other NOTCH receptors.