IL8 has been reported to promote cancer progression and metastasis mainly through its ability to attract and functionally regulate neutrophils and macrophages, not only recruiting neutrophils to tumor lesions, but also triggering the extrusion of neutrophil extracellular traps (42), which is very important for the regulation of tumor microenvironment and anti-tumor immunotherapy (43). This evidence concerns the gene CXCL8 and cancer.