Knocking down USP8 in SH-SY5Y cells promotes αS degradation through lysosomes and USP8 silencing in a Drosophila model of PD rescues αS-induced toxicity (rough eye phenotype, climbing function, and TH-positive neuron loss), while knockdown of the ESCRT I protein, Vps28, enhanced the rough eye phenotype (Alexopoulou et al., 2016). Here, UBE3A is linked to Parkinson disease.