TNFAIP1 was identified as a tumor necrosis factor-α (TNF-α)–inducible protein with involvement in various cellular processes such as the cytokinesis signaling pathway, DNA synthesis, innate immunity, apoptosis, and it is believed to be relevant to diseases such as Alzheimer’s disease (52) The role of TNFAIP1 in the development of cortical neurons and its impact on neurological functions are likely to play a crucial role in human brain development and disease. Here, TNF is linked to early-onset autosomal dominant Alzheimer disease.