ERN1 and neoplasm: In this report, we demonstrate that the mammalian Ire1 inhibitor 4μ8C, which blocks tumor growth in various pre-clinical models, inhibits the growth of several A. fumigatus isolates and can furthermore block the development of FK when applied topically to the corneal surface (Qiu et al., 2013; Stewart et al., 2017; Pavlović et al., 2020).